I just klicked on a notification of a comment in my inbox. I therefore found that loading a comment via direct link (like this) breaks the site and the content is moved so that the comment appears in the top left corner of the window.
I could reprodue this on IE11 11.0.9600.18204 (Windows 7) - but not on Safari 9.1 11601.5.17.1 (MacOS X El Capitan) so this seems to be an IE problem?
This also happens when clicking on the answered x hours ago link in the overview. My best guess would be that this happens everytime an anchor is used. Clicking on a asked x hours ago message works fine.