Interesting idea. I'll say that it is on topic.
The ideal question here would be along the lines of
If [A] happens, will it create a mass extinction?
This has a definite answer (either yes or no). There's no subjectivity.
If you were to ask
How can I create a mass extinction?
then you're venturing into uncertain waters. In general, this kind of thing can be Too Broad, but here it might be okay, because very few things can (realistically) cause a mass extinction. You'll probably get some wacky answers about gamma-ray bursts and the like, but those are impossible for the immediate future. Only a small amount of events could cause a mass extinction.
If you phrase it as
What is the best way of starting a mass extinction?
then you're in trouble, because "best" is usually subjective. You'd need to give a set of hard, definite criteria for this to work. See the blog post Good Subjective/Bad Subjective, as well as How do I create open ended questions with subjective answers? right here on Worldbuilding meta.
I think that if you attack it the right way, the question will be fine. Although I don't think anyone has ever asked about them before on Worldbuilding (cue someone proving me wrong), mass extinctions are on-topic here.