If a question is asked well -- shows research or analysis, is well-asked, etc -- and is arguably in our space, I generally won't downvote it even if I vote to close it. Especially on a beta site where we're still working out some scope boundaries, we can't expect everybody to guess right on the first try. If a question comes in here that should be moved to Chemistry or Physics or Space Exploration or Health or RPG or Parenting, let's help the asker and migrate it.
If a question has nothing to do with worldbuilding, like if somebody asks a question about Python (and he's not talking about alternate worlds or the future or snakes), I may well downvote it no matter how well or badly it's written. The asker may have showed effort in formulating his question but he doesn't seem to have shown effort in deciding where to ask it. Again, if we can help him out with a migration, let's do it and no harm done.
https://worldbuilding.stackexchange.com/questions/20895/chemistry-help-needed-molar-solubility doesn't show much research effort and its connection to worldbuilding is, err, non-obvious. I didn't vote, but I understand why some people downvoted it. In its present form it doesn't appear to meet the requirements over on Chemistry, so it's not a good migration candidate.
https://worldbuilding.stackexchange.com/questions/20872/how-to-align-all-the-definitions-in-a-symbol-list-word-2010 doesn't seem to have anything to do with worldbuilding. I left a comment (though I could have been more verbose) and closed it. The asker hasn't been back since then. This question might be on-topic on SuperUser; I think I'll just migrate it.
Downvotes don't follow a question to its new home, so the fact that voters here found it a poor fit and voted accordingly does not harm the question (or its author) at the migration site. And eventually the migration "stub" left here gets deleted, I'm pretty sure, so even the local rep loss is temporary.